MR-PRESSO analysis identified five influential outlier which were the TFAP2B variant, rs987237 (outlier test p-value < 0.017), the faim2 variant rs7138803 (outlier test p-value = 0.153), the ETV5 variant rs9816226 (outlier test p-value = 0.493), a NEGR1 obesity locus rs7531118 (outlier test p-value < 0.017), and rs527248 (outlier test p-value = 0.017) which were also shown to be a clear outlier in both scatter and leave-one-out plots (Figs. 1 and 2). This evidence concerns the gene NEGR1 and obesity due to melanocortin 4 receptor deficiency.