Indeed, OC treatment in AYAs with PCOS fails to normalise insulin resistance, the circulating levels of ultra-sensitive C-reactive protein (us-CRP, a marker of low-grade inflammation), the carotid intima-media thickness (cIMT, a marker of subclinical atherosclerosis) or the ectopic fat [13, 27–30]. The gene discussed is CRP; the disease is atherosclerosis.