Regarding dosage and schedule, in the first-in-human phase I study, CP0001, quizartinib was administered with intermittent dosing (14 days on drug followed by 14 days rest) from 12 to 450mg and continuous dosing at 200mg and 300mg for 28 days in 76 patients with r/r-AML, regardless of FLT3-ITD mutation status [13]. This evidence concerns the gene FLT3 and acute myeloid leukemia.