APP and Alzheimer disease: To better understand which disease stage was modelled within the human grafted AD cells, we compared the proteomic changes taking place in human cells in ADHG with those in APP variant hippocampal spheroids (ADHS) grown for 100 days in vitro [7] and human AD hippocampal postmortem brain tissue (ADHPMBT; Additional file 4: Table S3), representing early and end stage AD, respectively.