The NLRP3 inflammasome has been implicated in various types of cancer, such as breast, lung, prostate, colorectal, bladder and melanoma. However, its role in cancer is complex and context-dependent, as it can exert both pro-tumorigenic and anti-tumorigenic effects. Therefore, understanding the mechanisms and consequences of NLRP3 inflammasome activation in cancer is crucial for developing novel therapeutic strategies [50]. This evidence concerns the gene NLRP3 and melanoma.