MAPK8 and breast carcinoma: For instance, In gastric cancer, the NLRP3 inflammasome enhances cell differentiation and induces IL-1β production, which activates NF-κB and JNK signalling, leading to proliferation, invasion, and cancer development or In breast cancer, the NLRP3 inflammasome and IL-1β production promote the infiltration of myeloid cells, providing an inflammatory microenvironment that promotes breast cancer progression [22].