One proposed mechanism of how CRC progression is influenced by NLRP3 inflammasome activation is that it triggers the secretion of pro-inflammatory cytokines, such as interleukin-1β (IL-1β) and interleukin-18 (IL-18). These cytokines can enhance tumor cell growth, survival, invasion, angiogenesis and immune escape [113, 114]. This evidence concerns the gene IL1B and neoplasm.