The nine enriched KEGG pathways included the Estrogen signaling pathway (hsa04915), Rap1 signaling pathway (hsa04015), Tight junction (hsa04530), Neurotrophin signaling pathway (hsa04722), Fluid shear stress and atherosclerosis (hsa05418), MAPK signaling pathway (hsa04010), Thyroid cancer (hsa05216), Bladder cancer (hsa05219), and Pathways in cancer (hsa05200) (Fig. 7B). The gene discussed is BDNF; the disease is thyroid cancer.