Several studies have explored the association between HLA-DRA and cancers and suggested a role HLA-DRA played during the development of multiple cancers including diffuse large B cell lymphoma [69], endometrial cancer [70], prostate cancer [71], hepatocellular carcinoma [72], cervical cancer [73], bladder cancer [74], colorectal cancer [75], and ovarian cancer [76]. Here, HLA-DRA is linked to colorectal cancer.