The germline abnormalities of A20 (encoded by TNFAIP3) lead to the overactivation of NF-κB pathway in the continuous stimulation of B cells by autoimmunity, and the uncontrolled activation of NF-κB pathway promotes the survival of germline B cells and accumulate oncogenic mutations, which enhance the risk of lymphoma [57]. The gene discussed is NFKB1; the disease is Autoimmunity.