Those genes were incorporated into a multivariable cox model to identify the independent risk factors, and 9 genes, including SLC16A12, ASPA, SMIM24, FLRT3, LAMB3, PLG, IL20RB, CXCL5, PDK4, were identified as independent risk factors for ccRCC (Fig. 7D, Table S6). This evidence concerns the gene FLRT3 and nonpapillary renal cell carcinoma.