ERBB2 and neoplasm: It can be seen from the plot that the top enriched upregulated TF was FOXO3 which is known to be upregulated by lapatinib in HER2 + cells [46], and the top enriched downregulated TF was ESRRA which is known to be degraded in response to lapatinib-mediated inhibition of growth factor-induced signalling in HER2 + tumours [47].