Moreover, the positivity of SALL4, which is a putative key transcription factor of progenitor-subtype HCC and reportedly exhibits higher positivity in HCCs than EpCAM [31, 32], was comparable between polyploid and near-diploid HCCs (43.5% vs. 40%, Fig. S4B). This evidence concerns the gene SALL4 and hepatocellular carcinoma.