On the other hand, a small study of 6 FMF patients [77] reported unchanged Treg frequencies in FMF patients at different stages of febrile attacks compared to the healthy control group [77] despite the increased concentration of Treg-related cytokines such as IL-10 and TGF-ß in the circulation of FMF patients [75, 78]. The gene discussed is IL10; the disease is familial Mediterranean fever.