In a study that examined AST/ALT ratio as a prognostic factor in patients with radiation-recurrent PC who underwent a salvage radical prostatectomy, the median AST/ALT ratio was 1.3322, while Miyake et al. reported a median AST/ALT ratio of 1.35 in CRPC patients before treatment24. This evidence concerns the gene GOT1 and pachyonychia congenita.