Our results demonstrated that age, race, insurance, marital status, NT-proBNP, HDL, lactate, CAR, SOFA, Amoxicillin Clavulanic Acid, Cefazolin, Ceftazidime, Ceftriaxone, Ciprofloxacin HCl, Daptomycin, Dobutamine, Dopamine, Erythromycin, Heparin, Metronidazole Flagyl, Miconazole, Omeprazole, and Pantoprazole were independent prognostic factors for sepsis patients. Here, NPPB is linked to Sepsis.