Based on the results of multivariate Cox regression analysis, 23 independent prognostic factors, including age, race, insurance, marital status, NT-proBNP, HDL, lactate, CAR, SOFA, Amoxicillin Clavulanic Acid, Cefazolin, Ceftazidime, Ceftriaxone, Ciprofloxacin HCl, Daptomycin, Dobutamine, Dopamine, Erythromycin, Heparin, Metronidazole Flagyl, Miconazole, Omeprazole, Pantoprazole, were included in the construction of the nomogram for predicting the in-hospital death of sepsis patients, and the predictive model was also validated using the validation cohort (Fig. 3). This evidence concerns the gene NPPB and Sepsis.