Median plasma level of Nesfatin-1 in adolescents with depression was 37.3 pg/ml (22.1 pg/ml, 63.6 pg/ml), while that in healthy adolescents was 18.1 pg/ml (10.0 pg/ml, 25.7 pg/ml) (Table 1); hence, adolescents with depression had significantly higher Nesfatin-1 levels than healthy adolescents (p < 0.001). Here, NUCB2 is linked to major depressive disorder.