NUCB2 and major depressive disorder: Median plasma Nesfatin-1 levels in the severe depression group, mild-to-moderate depression group, and control group were 53.4 pg/ml (28.2 pg/ml, 149.1 pg/ml), 29.9 pg/ml (14.5 pg/ml, 48.5 pg/ml), and 18.1 pg/ml (10.0 pg/ml, 25.7 pg/ml), respectively (Table 3), and there was a significant difference in Nesfatin-1 levels among the three groups (H = 29.3, P < 0.001).