Next, owing in part to the transcriptome changes, we looked at the percentage of central-memory T cells (TCM), defined as CD45RA-CD62L+ cells, and found the percentage to be significantly higher in normal donor PBMC-derived B7-H3 CAR T cells following repetitive co-culture in separate experiments with three types of stressed cancer cells (stressed repetitive co-culture) compared with non-stressed cancer cells (regular repetitive co-culture) (Fig. 2b–d). Here, SELL is linked to cancer.