Then, strong and sustained cytotoxicity on a panel of different target cancer cells and increased release levels of IFN-γ and TNF-α were found in normal donor PBMC-derived B7-H3 CAR T cells or CSPG4 CAR T cells, respectively, following repetitive co-culture with stressed tumor cells (Fig. 3e–i and Supplementary Fig. 3d–f). The gene discussed is IFNG; the disease is cancer.