Although Cas9-induced single-strand template repair (SSTR) requires the Fanconi anemia pathway, with genome editing efficiency via SSTR severely reduced in FANCA-depleted cells44, a disruption of the FANCA gene in TK6261 cells (Supplementary Figure 14e, f) only partially reduced the MN-mediated gene correction efficiency (to approximately 75%) (Fig. 6f). This evidence concerns the gene FANCA and Fanconi anemia.