Here, we describe a proof‐of‐concept amplitude modulation‐based multiplex dPCR assay capable of detecting 12 single‐nucleotide and insertion/deletion (indel) variants in EGFR, KRAS, BRAF, and ERBB2, 14 gene fusions in ALK, RET, ROS1, and NTRK1, and MET exon 14 skipping present in non‐small cell lung cancer (NSCLC). The gene discussed is EGFR; the disease is non-small cell lung carcinoma.