It remains to be seen whether the extent to which the functional network alterations reported here are more closely related to the presence of tau pathology (Steward et al., 2023) and whether they are specific to AD, especially as other forms of dementia typically impact unique sets of brain regions and are accompanied by distinct types of behavioral impairments (e.g., behavioral variant frontotemporal dementia, vascular dementia, Parkinson disease, atypical AD; Filippi et al., 2013, 2017; Gratton et al., 2019; Singh et al., 2023). The gene discussed is MAPT; the disease is vascular dementia.