A recent study showed that COL1α1 was upregulated in left ventricular heart tissue from patients with heart failure and that plasma levels were increased in those who were candidates for heart transplant.27 However, the MI cohort in our study included only 16 patients with moderate or severe left ventricular dysfunction, which does not permit us to draw conclusions about the relationship between COL1α1 and heart failure. Here, COL1A1 is linked to heart failure.