Recently, we performed an exploratory study using relative quantification of 184 cardiovascular disease-related proteins to identify plasma biomarkers that predicted CAD over a 13-year follow-up period in a population-based Swedish cohort.18 Interestingly, COL1α1 was significantly and inversely associated with the risk of first-time major event of CAD. This evidence concerns the gene COL1A1 and coronary artery disorder.