IGHE and atopic eczema: Additionally, MCD is frequently observed in patients with bronchial asthma and atopic dermatitis, and the relationship between IgE-mediated type I allergy and MCD has been highlighted.35–37 In this case, the background disease was atopic dermatitis, and the blood test at the time of admission showed high IgE levels, indicating that the patient was predisposed to hypersensitivity and developing MCD following vaccination.