The strongest individual predicted ligand activity of P1 cells was VEGFA, followed by a set of cytokines (IL1b and IL15) and FGF2. For P2 cells, the ligands with the strongest individual activity were IL24 and FGF5. The corresponding tEC receptors are shown in Figure 6E. All inferred cytokines have proven pro- or anti-angiogenic function in cancer angiogenesis (Table S4); however, their function during neovascularization and vessel maturation is unknown. Here, VEGFA is linked to cancer.