CRP and systemic lupus erythematosus: Consequently, in addition to cardiovascular disease, statins may also be used in immune-inflammatory diseases, including RA and systemic lupus erythematosus.[13–17] For clinical research data integration, machine learning and meta-analysis have become critical.[18–20] Meta-analysis by Sahebkar et al[21] suggests that statins were safe in treatment of systemic lupus erythematosus patients and may reduce cardiovascular risk through lowering C-reactive protein (CRP) levels.