Literature reported chrysoeriol can bind to the protein kinase domain of Src and inhibit p-Src in melanoma cells and tissues, thus participating in the growth and metastasis of melanoma.[9] Simultaneously, chrysoeriol can slow down the progression of OVA-induced asthma in mice by inhibiting NF-κB/HIF-1α and MAPK/STAT1 pathways, which is consistent with the GO enrichment results.[10]. Here, HIF1A is linked to melanoma.