CASC8 and Familial prostate cancer: Studies have shown that CASC8 is associated with the occurrence and prognosis of multiple types of solid tumors, such as colorectal cancer, prostate cancer, and upper gastrointestinal cancer.[58–60] Moreover, CASC8 expression was significantly different in different pancreatic cancer cell lines, with high expression in MIA PaCa-2 cells, but deficient in PANC-1 cell lines.[61] Therefore, we performed further experiments to detect the expression of CASC8 in Chinese pancreatic tissues.