MACC1 and pancreatic adenocarcinoma: For instance, MACC1-AS1, an lncRNA frequently expressed in PAAD tissues, is particularly overexpressed in patients with poor survival.[9] A previous study elucidated the involvement of lncRNAs in the development and treatment of PAAD as carcinogenic factors or tumor suppressors, thus highlighting lncRNAs as potential diagnostic and therapeutic targets.[10–13]