KRAS and pancreatic adenocarcinoma: It is now generally believed that genomic instability may have greater diagnostic potential for early detection of cancer.[14] Recent studies have found that molecular subtypes of pancreatic cancer are associated with specific copy number abnormalities of mutated genes such as Kirsten rat sarcoma viral oncogene homolog (KRAS).[15] KRAS is a member of the RAS family encoding small GTPases and the mutation exists in approximately 85% of pancreatic ductal adenocarcinoma and in early-stage PAAD.