A few studies have shown that CASC8 promotes cell proliferation in retinoblastoma and non-small cell lung cancer.[40,41] As an inflammation-related lncRNA, AC015660.1 predicts the prognosis of gastric cancer.[42] AC015660.1 also can be used as an angiogenic factor-related lncRNAs to evaluate the prognosis of pancreatic cancer.[43] In our study, AC015660.1, as a genomic instability-associated lncRNA, was involved in predicting the prognosis of pancreatic cancer, indicating that AC015660.1 may be a potential target for PAAD treatment. The gene discussed is CASC8; the disease is pancreatic adenocarcinoma.