Additionally, excessive concentrations of SUA are generally considered to be a mediator of inflammatory endocrine disorders in adipose tissue, which may be a significant contributing factor to the development of dyslipidemia.[28] Previous studies have demonstrated that elevated levels of SUA promote the formation of foam cells, decrease cell viability, and increase iron accumulation and lipid peroxidation in macrophages.[29] Furthermore, Experimental research has suggested that uric acid may induce hepatic fat accumulation through the activation of the ROS/JNK/AP-1 pathway.[30]. Here, MAPK8 is linked to metabolic syndrome.