TNF and gestational diabetes: Studies have shown that GDM has a much higher affinity for TNF than IFX and ADA, and it is also superior to IFX and ADA in terms of conformational stability and inhibition of tumor necrosis factor-induced cytotoxicity.[104] In a multicenter, randomized, double-blind, controlled study, the proportion of patients in clinical remission and mucosal healing at weeks 30 and 54 was higher in patients receiving 100 mg GDM (27.8% and 42.4%) than in those receiving placebo (15.6% and 26.6%; P = .004 and P = .002 respectively).[105]