THL may act on biological targets such as ALB, EGFR, SRC, HSP90AA1, STAT3, EGF, and ESR1 through active ingredients such as quercetin, salidroside, luteolin, etc., and participate in the regulation of JAK/STAT, Hemostasis, ERK, and other signaling pathways to play a role in the treatment of PF. Here, MAPK1 is linked to pemphigus foliaceus.