THL may act on biological targets such as ALB, EGFR, SRC, HSP90AA1, STAT3, EGF, and ESR1 through active ingredients such as quercetin, salidroside, luteolin, etc., and participate in the regulation of JAK/STAT, Hemostasis, ERK, and other signaling pathways to play a role in the treatment of PF. This evidence concerns the gene ESR1 and pemphigus foliaceus.