THL may act on biological targets such as ALB, EGFR, SRC, HSP90AA1, STAT3, EGF, and ESR1 through active ingredients such as quercetin, salidroside, luteolin, etc., and participate in the regulation of JAK/STAT, Hemostasis, ERK, and other signaling pathways to play a role in the treatment of PF. The gene discussed is STAT3; the disease is pemphigus foliaceus.