Platelets, neutrophils, and lymphocytes, which can aggregate in vessels and release factors, such as vascular endothelial growth factor, TGF-β, and platelet-derived growth factor, can affect the biological behavior of cancer cells.[40–44] Thrombopoietin and inflammatory mediators released by cancer cells may stimulate platelet growth, and in turn, tumor growth. This evidence concerns the gene THPO and cancer.