Albumin is a significant indicator of acute-phase proteins and systemic chronic inflammation.[53] Its use is widespread in reflecting the overall nutritional status of the body and is considered a promising prognostic factor for various malignancies.[54,55] During inflammation, pro-inflammatory cytokines such as interleukin-1, interleukin-6, and tumor necrosis factor-α can inhibit the production of albumin.[56,57] A low serum albumin level may indicate that the host is experiencing malnutrition, which can negatively impact the overall health. The gene discussed is TNF; the disease is malnutrition.