The estimated filtration values of cancer-associated fibroblasts were found to be statistically positively correlated with SPON2 expression in TCGA tumors of BLCA, CESC, BRCA-LumA, TGCT, HNSC, and HNSC [Human papillomavirus (Human papillomavirus) +/−], as shown in Figure 5. The gene discussed is SPON2; the disease is cancer.