Concurrently, The top 10 genes with high correlation between SPON2 monogenes and other pan-oncogenes were TRPV6, NKX3-1, STEAP2, TRPM4, PLPP1, ALDH1A3, DHRS7, RDH11, TRPM8, and PMEPA1.TRP channels, Primary alcohol metabolic process, PID AR TF pathway, Alcohol metabolic process, Monoatomic ion transmembrane transport, Organic hydroxy compound metabolic process, Transport of small molecules, Monoatomic cation homeostasis, Monoatomic ion homeostasis, Regulation of hormone levels were the top ten pathways with high correlation between SPON2 monogene and other pan-cancer pathways (Fig. 6E). This evidence concerns the gene RDH11 and cancer.