Ming Wu et al(2023) found that SPON2 promotes the bone metastasis of lung adenocarcinoma via activation of the NF-κB signaling pathway.[45] According to Chen et al,[46] Tumor-derived exosomes HOTAIRM1 can transfer to CAFs, regulate the expression of SPON2 in CAFs cells, and ultimately promote the progression of NSCLC. This evidence concerns the gene SPON2 and lung adenocarcinoma.