Ming Wu et al(2023) found that SPON2 promotes the bone metastasis of lung adenocarcinoma via activation of the NF-κB signaling pathway.[45] According to Chen et al,[46] Tumor-derived exosomes HOTAIRM1 can transfer to CAFs, regulate the expression of SPON2 in CAFs cells, and ultimately promote the progression of NSCLC. The gene discussed is HOTAIRM1; the disease is neoplasm.