SPON2 is expressed in a variety of cell types and plays a role in cell adhesion, migration, and differentiation.[3,21,29,30] It is a host innate immune regulator, which represents a unique pattern-recognition molecule in the ECM for microbial pathogens.[31] Notably, SPON2 also acts as an integrin-ligand for inflammatory cell recruitment and T cell activation.[32,33] The binding of SPON2 to bacteria promotes phagocytosis in bacteria and stimulates macrophages to produce pro-inflammatory cytokines.[34] There were no pan-cancer studies of SPON2 that we could locate in the literature. The gene discussed is SPON2; the disease is cancer.