SLC7A11 and laryngotracheoesophageal cleft: In the System Xc-, SLC7A11 and SLC3A2 are linked by a disulfide bond and co-mediate the transport of cystine and glutamate, which are the main compositions of glutathione, the most abundant cellular antioxidant.[17] It has been reported that SLC7A11 participated in the progression and development of many malignancies, including LC.