FOLH1 and neoplasm: HIF-1α binds HIF-1β to form HIF-1, an intranuclear transcription factor that induces angiogenesis under hypoxic conditions.[13] HIF-1α is also a co-activator of estrogen-induced vascular endothelial growth factor in both normal endometrial tissues and EC.[14] Recently, neovascular PSMA expression has been associated with tumors and hypoxia severity.[15] In this study, HIF-1α and PSMA were overexpressed in UEC and OCC, suggesting that both tumor types are hypoxic, regardless of their primary site or morphological features.