Furthermore, ADAM9 wild type (ADAM9-WT) significantly increased SARS-CoV-2 Spike Vpp infection but not VSV-G, whereas a catalytically inactive ADAM9-E348A mutant did not affect both SARS-CoV-2 Spike and VSV-G Vpp infection compared with mock (Fig. 5C). The gene discussed is CHMP5; the disease is infection.