Importantly, the deactivationof the Rbp1 gene does not cause pathological changesin the murine retina.31 Additionally, mutationsin the RBP1 gene have not been reported to cause human retinal disorders.33 Thus, the physiological function of CRBP1 preordainsthis protein as a pharmacological target for controlling the fluxof retinoids in the eye without causing serious ocular side effects. The gene discussed is RBP1; the disease is retinal disorder.