Since the previous studies have explored the role of the signature genes METTL7B, SSTR2, OXTR, CDKN2C, and H19 in glioma, while TNFRSF11B has been poorly studied, we examined the functional impact of TNFRSF11B on LGG cell behavior [39–44]. This evidence concerns the gene TNFRSF11B and central nervous system cancer.