The AUC values for pancreatic cancer diagnosis by serum EphA2-NF or CA19-9 (vs. HDs) were 0.99 and 0.93, respectively, suggesting that serum EphA2-NF was superior to CA19-9 for pancreatic cancer diagnosis (Fig. 2F). This evidence concerns the gene EPHA2 and familial pancreatic carcinoma.