To analyze the state of EphA2 cleavage in vivo, IHC for EphA2 N- and C-termini was performed in the normal duct epithelium, IPMN with and without pancreatic cancer, and pancreatic cancer tissues (Fig. 6A and B). This evidence concerns the gene EPHA2 and pancreatic intraductal papillary-mucinous neoplasm.