In summary, these results suggest that EphA2 N-terminus deletion is involved in pancreatic cancer development from IPMN and that EphA2-NF produced by cleavage can be used as a biomarker to diagnose pancreatic cancer and predict pancreatic cancer development from IPMN. Here, EPHA2 is linked to pancreatic intraductal papillary-mucinous neoplasm.