The EphA2 N-terminus staining score was significantly reduced in IPMN with pancreatic cancer compared with that in the normal duct epithelium, whereas there was no significant difference in staining between IPMN without pancreatic cancer and the normal duct epithelium (Fig. 6B). Here, EPHA2 is linked to pancreatic intraductal papillary-mucinous neoplasm.