However, there were no significant differences in EphA2 C-terminus staining between normal ductal epithelium, low-grade IPMN, high-grade IPMN, IPMN with pancreatic cancer, IPMN without pancreatic cancer, and high-grade IPMN with pancreatic cancer, even when examining multiple lesions with different malignancies in the same specimen separately (Fig. 6C and D). Here, EPHA2 is linked to familial pancreatic carcinoma.