EPHA2 and pancreatic intraductal papillary-mucinous neoplasm: In addition, IHC analysis of IPMN cases with and without pancreatic cancer showed that all tissues with pancreatic cancer had a defect in the N-terminus of EphA2, which was detected in both high-grade and some low-grade IPMN cases, suggesting that EphA2 cleavage occurred regardless of histologic grade.