However, there were no significant differences in EphA2 C-terminus staining between normal ductal epithelium, low-grade IPMN, high-grade IPMN, IPMN with pancreatic cancer, IPMN without pancreatic cancer, and high-grade IPMN with pancreatic cancer, even when examining multiple lesions with different malignancies in the same specimen separately (Fig. 6C and D). This evidence concerns the gene EPHA2 and pancreatic neoplasm.