IL-5 is aprototypical T helper cell type 2 (Th2) cytokine, and IL-33 is believed to have aprotective effect on brain inflammation and cognitive decline.(43) Another intriguing factor is thatAβ (1-40) and Aβ (1-42) are not related to long-term cognitiveimpairment. This evidence concerns the gene IL33 and Mental deterioration.