IL6 and neoplasm: Pancreatic Reck deletion was found to result in the emergence of αSMA-low/IL-6–high mesenchymal (vimentin-positive) CAF-like cells via EMT of PDAC cells (Supplemental Figures 6 and 7), which share a similar expression pattern of marker proteins with a tumor-promoting type of CAF, termed inflammatory CAF (iCAF) (18, 34).