ALDH18A1 and hereditary spastic paraplegia: It has been identified in at least three probands by clinical testing (ClinVar SCV001929264.1, SCV001952732.1, and SCV001970262.1) and is classified as likely pathogenic for AR HSP (in each proband, the variant was confirmed in trans with another ALDH18A1 VUS and the parents were unaffected heterozygous carriers).