TNXB and Ehlers-Danlos syndrome: The classical-like type of EDS (clEDS) is an autosomal recessive disorder caused by complete absence of tenascin-X (TNX) resulting from biallelic variation in TNXB. The major criteria of clEDS include: 1) skin hyperextensibility, with velvety skin texture and absence of atrophic scarring; 2) generalized joint hypermobility, with or without recurrent dislocations; and 3) easily bruisable skin/spontaneous ecchymosis.