Patients with PADI6 mutation showed early embryonic arrest, zygotic cleavage failure, recurrent hydatidiform moles and other different phenotypes (Alazami et al., 2015; Wang et al., 2018; Mu et al., 2019; Lin et al., 2020; Maddirevula et al., 2020; Xu et al., 2020; Sang et al., 2021; Zheng et al., 2021; Dong et al., 2022). This evidence concerns the gene PADI6 and hydatidiform mole.