Our findings showed that acupuncture was closely associated with a decrease in the level of LDL-C and an increase in the level of lipoprotein α and Apo A1, and slightly increased the ratio of Apo A1/Apo B in lipid profiles in patients with PCOS, while the sham acupuncture group could increase the TC level. The gene discussed is APOB; the disease is polycystic ovary syndrome.