We also discovered 14 hub genes, including TYROBP, CD44, BGN, FCGR3A, CD53, CXCR4, FN1, SPP1, IGF1, CCND1, MMP9, IL2RG, IL6 and CTGF, which were crucial in the development of CC and obesity. This evidence concerns the gene CD53 and obesity due to melanocortin 4 receptor deficiency.