We also discovered 14 hub genes, including TYROBP, CD44, BGN, FCGR3A, CD53, CXCR4, FN1, SPP1, IGF1, CCND1, MMP9, IL2RG, IL6 and CTGF, which were crucial in the development of CC and obesity. Here, IGF1 is linked to obesity due to melanocortin 4 receptor deficiency.