We expected that the transcription factors WRNIP1, ATF1, CBFB, and NR2F6, as well as the microRNAs miR-1-3p, miR-26b-5p, miR-164a-5p, and miR-9-5p, would play essential roles in metabolic abnormalities of cells in obese people and the development of colon cancer. This evidence concerns the gene WRNIP1 and colonic neoplasm.