Magnesium deficiency is associated with low-grade chronic inflammation involving the proinflammatory cytokines TNF-α and IL-1, the messenger IL-6, as well as E-selectins, intracellular adhesion molecule-1 (ICAM-1), and vascular cell adhesion molecule-1 (VCAM-1), acute-phase reactants - C-reactive protein and fibrinogen (137). The gene discussed is VCAM1; the disease is magnesium deficiency.