MAP1LC3A and obesity due to melanocortin 4 receptor deficiency: Here, we observed a lower conversion from LC3-I to LC3-II, a standard marker for autophagosomes, accompanied by the suppression of PNIK1 and higher levels of p62 in the mice myocardium after exhaustive exercise, indicating that obesity significantly suppressed mitophagy in response to fatal stress (Figures 4A-D).