Based on those observations, in the present study, we aimed to evaluate the effect of the IgG repertoires obtained from asymptomatic, HAM/TSP, and ATLL donors on the production of cytokines by peripheral αβT- (CD4+ and CD8+), γδT- and B-cells searching for the identification of differential immunological signatures that may be related to each clinical manifestations resultant from HTLV-1 infection. Here, CD8A is linked to tropical spastic paraparesis.