AIM2 and heart failure: Additionally, Panx1 has been found to promote AIM2 (absent in melanoma 2) activation, contributing to neuronal damage in conditions like subarachnoid hemorrhage (40), myocardial death in heart failure (41), pyroptosis of retinal cells due to ocular hypertension (42), and inflammatory response of Kupffer cells following hepatic ischemia-reperfusion injury (43).