Genes associated with glucose intolerance phenotype included genes related to ECM/cell-cell interaction (BGN, COL4A1, PRSS23, TNC, TAGLN). Overall, MP1 differentiates between normoglycemic individuals and glucose intolerant individuals with the tissue program shifting towards genes related to cytotoxicity, inflammation, lipid metabolism, macrophage activation, and ECM deposition (Supplementary Figure 8E). The gene discussed is PRSS23; the disease is Glucose intolerance.