ISG15 and diabetes mellitus: The macrophage compartment MP1 expression program was also not as strongly associated with diabetes status as the T cell compartment but did show enrichment of genes associated with M2 macrophage polarization (KLF4, MAFF, MAFB, ATF4, EGR1, EGR2) and chemotaxis (CCL2,CXCL8) in MP1 upregulated compartment, and enrichment of genes associated with lipid metabolism (TREM2), IFN-γ (IFI27, ISG15), and macrophage activation (AREG) in MP1 downregulated compartment (Supplementary Figures 8A–C).