In PWH with glucose intolerance, we found higher proportion of lipid-associated macrophage (LAM) and LAM-like macrophage populations, reduction of perivascular macrophages (PVMs), and an increase in CD4+ and CD8+ T effector memory (TEM) populations that was independent of obesity, age, and sex. Here, CD8A is linked to obesity due to melanocortin 4 receptor deficiency.