We also evaluated predicted signaling from myofibroblast (Figure 8D) and preadipocytes (Figure 8E) to IMs, which showed increased MHC-II, CD99, MIF, periostin, amyloid beta precursor protein (APP), and CSF signaling pathways with glucose intolerance and have been implicated in macrophage polarization (92–94). Here, APP is linked to Glucose intolerance.