With the downregulation of the membrane-attack complex member c7 gene, its function and expression have been observed in response to infection in fish (73), and the modulation of several viral processes and antiviral genes (i.e., trim25, pvr, f11r, among others) suggest that the supplementation of D. hansenii in low fish meal-based diets is capable of modulate and regulate immune functions in the skin of S. aurata. Here, TRIM25 is linked to infection.