TNFSF10 and chronic kidney disease: However, the IVW-FE analysis revealed that lower levels of TNF-related apoptosis inducing ligand (TRAIL) were associated with a higher risk of CKD (OR=0.968, 95% CI 0.938 - 0.999, P = 0.047), which was observed in the IVW-RE, MR-Egger and weighted median analyses that were consistent.