CBL and Noonan syndrome: Previously, a heterozygous germline variant in CBL that was involved in the RAS-MAPK signaling pathway has been reported to cause Noonan syndrome-like phenotype with a predisposition to malignancies (57), while somatic mutations in CBL have been found to lead to myeloproliferative disorders including juvenile myeloid leukemia (JMML) (58).