Variants in the remaining 12 genes have been found to be associated with retinal vascular or inflammatory changes, including variants in five genes [CECR1 (18), IGFBP7 (19), MEFV (20), NOD2 (21), and TNFAIP3 (22)] reported to cause retinal macroaneurysms, vasculitis, or angiitis. The gene discussed is IGFBP7; the disease is vasculitis.